TB-500 (Thymosin Beta-4) Research Hub
TB-500 research resource — Thymosin Beta-4 fragment mechanisms, actin regulation, cell migration, wound repair, cardiac repair, and hair growth studies with PubMed citations.
Featured Research
In-depth research profiles with mechanisms of action, key findings, and peer-reviewed citations.
Thymosin Beta-4 (TB-500 Fragment)
Also known as: TB-500, TB500, Thymosin Beta 4, Tbeta4
Thymosin beta-4 (Tbeta4) is a 43-amino-acid peptide that is the most abundant member of the beta-thymosin family. Despite its name (a historical artifact from its original isolation from thymus tissue), Tbeta4 is expressed in virtually all nucleated cells and is one of the most abundant intracellular peptides, with concentrations reaching 0.4 mM in some cell types. TB-500 is a synthetic version co...
Quick Facts
Sequence: Full TB4: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe...
MW: 4921.0 g/mol (full Tbeta4)
CAS: 77591-33-4
Store lyophilized powder at -20C. Reconstituted solution should be refrigerated at 2-8C and used within 21 days. Tbeta4 ...
Latest Research Articles
Deep-dive articles from the System Peptides Research Network.
Essential Peptides for Anti-Aging and Longevity Research
The most studied peptides in aging research — Epitalon, NAD+, MOTS-c, GHK-Cu, and SS-31. Mechanisms, evidence levels, an...
Read Article Trending ResearchPeptide Research Trends to Watch in 2026
The five biggest trends shaping peptide research in 2026 — from GLP-1 agonist evolution to mitochondrial peptides, AI-dr...
Read Article Educational GuideUnderstanding Mass Spectrometry in Peptide Analysis
How mass spectrometry confirms peptide identity — ESI-MS, MALDI-TOF, and what molecular weight data means on your COA.
Read ArticleResearch Applications
Key research categories and applications studied in the scientific literature.
Recovery & Healing
TB-500 promotes angiogenesis and cell migration, making it highly effective for repairing soft tissue damage and enhancing flexibility in preclinical recovery models.
Lean Mass & Body Composition
Often paired with BPC-157 as a recovery stack — while not directly anabolic, TB-500 accelerates tendon/muscle repair, enabling more consistent training in research settings.
Skin & Soft Tissue
Promotes recovery, cell migration, and improves elasticity in connective tissue, supporting skin and soft tissue remodeling research.
Immune Support
Thymosin Beta-4 promotes T-cell production and accelerates tissue repair and healing, assisting recovery after illness or injury in immune research models.
Cognitive Enhancement
Primarily used for repair, TB-500 improves cognitive function by reducing systemic brain inflammation in neuroprotection research.
Frequently Asked Questions
Common questions about tb-500 research research, purity standards, and sourcing.
What is TB-500?
TB-500 is a synthetic 43-amino acid fragment of Thymosin Beta-4 (Tbeta4), a naturally occurring 6kDa actin-sequestering protein. It is studied for wound healing, tissue repair, cardiac regeneration, and anti-inflammatory effects in preclinical models.
How does TB-500 work?
TB-500 promotes cell migration by sequestering G-actin monomers, modulating the actin cytoskeleton, and upregulating cell surface receptors involved in tissue repair. It also promotes angiogenesis and reduces inflammatory cytokines.
What is the difference between TB-500 and Thymosin Beta-4?
TB-500 is a synthetic fragment of the full 43-amino acid Thymosin Beta-4 protein. It retains the active region responsible for actin binding and cell migration while being easier to synthesize at research-grade purity.
Ready to Start Your Research?
Browse our complete research library or visit Research Vials to source peptides.
Explore the System Peptides Research Network